Use of promethazine and codeine combination will not be advisable in little ones youthful than 6 a long time of age for syrup or in little ones young than 12 a long time of age for oral solution, as a result of increased danger of respiratory melancholy.
Breastfeeding. Do not consider promethazine/phenylephrine/codeine when you are breastfeeding. Promethazine/phenylephrine/codeine can go into breast milk. Convey to your Health care provider Should you be breastfeeding or plan to breastfeed.
Codeine use in little ones isn't recommended mainly because it may have unpredictable outcomes amongst folks and youngsters are more prone to overdose because of their smaller dimensions.
Consequently, ingestion from the advisable dose could produce drug amounts in breast milk that might exceed those reported earlier mentioned. The outcome of this exposure over a nursing infant is mysterious.
Codeine: A examine in rats and rabbits claimed no teratogenic outcome of codeine administered through the duration of organogenesis in doses starting from 5 to a hundred and twenty mg/kg. While in the rat, doses at the 120mg/ kg degree, during the toxic selection to the Grownup animal, were connected to an increase in embryo resorption at enough time of implantation.
The existence of the polymorphism in CYP2D6 results in non-operating enzyme variant and will be related to lessened therapeutic response when dealt with with codeine.
It works by selectively inhibiting the enzyme COX-two, which plays a crucial role within the creation of prostaglandins that cause inflammation and ache. Celecoxib is most well-liked more than Several other NSAIDs here because of its decrease chance of gastrointestinal side effects including ulcers and bleeding.
This drug is assessed to be a pregnancy Classification C drug. There won't be any enough and nicely-managed experiments finished in pregnant Females. Codeine really should only be used throughout pregnancy In case the likely profit outweighs the prospective risk from the drug towards the fetus Label. Codeine has revealed embryolethal and fetotoxic effects while in the hamster, rat and also mouse designs at about 2-four periods the utmost advised human dose Label.
It's important you dispose of unwanted opioid medicines securely. Unused medicines can be returned to any pharmacy. Will not hold unused codeine 'just in case'. This may result in perilous or inappropriate use.
常見之不良反應有：瘙癢、噁心、嘔吐、昏睡、口乾、瞳孔縮小、姿態性低血壓（orthostatic hypotension）、小便不暢、便秘。
Pregnancy Exams: Diagnostic pregnancy tests based upon immunological reactions among HCG and anti-HCG may perhaps lead to Phony-damaging or Untrue-favourable interpretations.
Narcotic analgesics result in histamine launch, which seems being responsible for wheals or urticaria often seen at the website of injection on parenteral administration.
Promethazine is contraindicated in comatose states, As well as in people today recognized for being hypersensitive or to acquire experienced an idiosyncratic reaction to promethazine or to other phenothiazines.
Promethazine is effectively absorbed through the gastrointestinal tract. Clinical effects are obvious inside of 20 minutes following oral administration and customarily past 4 to six hours, although they may persist as long as twelve hours. Promethazine is metabolized through the liver to a number of compounds; the sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites appearing during the urine.